Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm4(Ikbkb)Rsky targeted mutation 4, Klaus Rajewsky MGI:3687199 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal numbers of mature B cells including follicular and marginal zone B cells are produced
• spleens contain well-organized lymphoid architecture with normal follicles and distinct marginal zone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures
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• 1-2 days after crosslinking with BCR, there are more cells is S phase than in wild-type B cell cultures
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• B cell numbers are increased in spleens (130 x 106) compared to wild-type (56 x 106)
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• B cell hyperplasia is observed, with a significantly expanded population of marginal zone B cells
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• cells on average have a longer lifespan than wild-type B cells
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• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures
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• B cell numbers are increased in spleens (130 x 106) compared to wild-type (56 x 106)
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• B cell hyperplasia is observed, with a significantly expanded population of marginal zone B cells
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• cells on average have a longer lifespan than wild-type B cells
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• 1-2 days after crosslinking with BCR, there are less apoptotic cells than in purified wild-type B cell cultures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
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• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-Jtm1Cgn/Ightm4Cgn Tg(Cr2-cre)3Cgn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization
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• hyperplasia of B cells in the spleen and bone marrow at 550-600 days
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• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days
• clonal or oligoclonal plasma cell expansions
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• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens
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• enlarged spleens in mice 550-600 days of age
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• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization
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• hyperplasia of B cells in the spleen and bone marrow at 550-600 days
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• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days
• clonal or oligoclonal plasma cell expansions
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• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens
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• enlarged spleens in mice 550-600 days of age
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• enlarged spleens in mice 550-600 days of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• plasma cell formation is severely impeded 10 days after primary and secondary immunization
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• mice show increased numbers of germinal center B cells at day 10 after primary immunizations
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• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle
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• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization
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• plasma cell formation is severely impeded 10 days after primary and secondary immunization
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• mice show increased numbers of germinal center B cells at day 10 after primary immunizations
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• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle
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• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization
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• shortened survival, with 40% survival at around 500 days of age
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• mice succumb to a B cell-derived lymphoproliferative disease affecting spleen and lymph nodes, resembling human diffuse large B cell lymphoma
• mice develop clonal lymphomas consistent with activated B cell-diffuse large B cell lymphoma
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| non-Hodgkin lymphoma | DOID:0060060 |
OMIM:605027 |
J:167612 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• T cell independent type II antibody responses are restored
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• B-1a cell development continues to be defective
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• B-1a cell development continues to be defective
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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