Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(CUX1)Anep}
• Allele Name: targeted mutation 1, Alain Nepveu
• Allele ID: MGI:3687214
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hprt1^tm1(CUX1)Anep/Hprt1^+	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB)	MGI:3687325
ht2	Hprt1^tm1(CUX1)Anep/Hprt1^+	FVB.129P2-Hprt1^tm1(CUX1)Anep	MGI:4360519

Genotype
MGI:3687325

ht1

• Allelic Composition: Hprt1^{tm1(CUX1)Anep}/Hprt1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:113393 )

♀ • 33% of female mice develop a hematopoietic disorder and display enlarged spleens

enlarged spleen ( J:113393 )

♀

spleen hyperplasia ( J:113393 )

♀ • spleen enlargement results from myeloid hyperplasia

myeloid hyperplasia ( J:113393 )

♀

anemia ( J:113393 )

♀

decreased erythrocyte cell number ( J:113393 )

♀ • number of red blood cells is significantly decreased

decreased hematocrit ( J:113393 )

♀ • hematocrit is significantly decreased

decreased mean corpuscular hemoglobin concentration ( J:113393 )

♀ • hemoglobin concentration is significantly decreased

decreased B cell number ( J:113393 )

♀ • B cells are underrepresented in spleen, bone marrow, liver and blood of transgenic mice

increased leukocyte cell number ( J:113393 )

♀ • WBC numbers are significantly increased; in most cases, increase is due to increased neutrophil numbers

increased neutrophil cell number ( J:113393 )

♀ • there is an excess of neutrophils in blood, spleen, bone marrow and liver of mice, as wel as lungs and kidneys in many cases

abnormal spleen white pulp morphology ( J:113393 )

♀ • regions of white pulp are seen to be compressed

abnormal splenic cell ratio ( J:113393 )

♀ • spleens contain large number of cells resembling polymorphonuclear leukocytes; neutrophils, granulocytes and megakaryocytes are present in increased numbers compared to wild-type

abnormal hematopoietic system physiology ( J:113393 )

♀ • transgenic mice (33% incidence) are ~4 times more susceptible to the hematopoietic disorder than non transgenic littermates (8.6% incidence)

immune system

enlarged spleen ( J:113393 )

♀

spleen hyperplasia ( J:113393 )

♀ • spleen enlargement results from myeloid hyperplasia

myeloid hyperplasia ( J:113393 )

♀

decreased B cell number ( J:113393 )

♀ • B cells are underrepresented in spleen, bone marrow, liver and blood of transgenic mice

increased leukocyte cell number ( J:113393 )

♀ • WBC numbers are significantly increased; in most cases, increase is due to increased neutrophil numbers

increased neutrophil cell number ( J:113393 )

♀ • there is an excess of neutrophils in blood, spleen, bone marrow and liver of mice, as wel as lungs and kidneys in many cases

abnormal spleen white pulp morphology ( J:113393 )

♀ • regions of white pulp are seen to be compressed

abnormal splenic cell ratio ( J:113393 )

♀ • spleens contain large number of cells resembling polymorphonuclear leukocytes; neutrophils, granulocytes and megakaryocytes are present in increased numbers compared to wild-type

enlarged lymph nodes ( J:113393 )

♀ • one mouse had enlarged lymph nodes containing mostly B cells

liver/biliary system

abnormal liver morphology ( J:113393 )

♀ • livers of sick mice have unusual color and texture; there is an overrepresentation of leukocytes in the livers

respiratory system

abnormal lung morphology ( J:113393 )

♀ • lungs of sick mice have unusual color and texture; there is an overrepresentation of leukocytes in the livers

growth/size/body

enlarged spleen ( J:113393 )

♀

spleen hyperplasia ( J:113393 )

♀ • spleen enlargement results from myeloid hyperplasia

Genotype
MGI:4360519

ht2

• Allelic Composition: Hprt1^{tm1(CUX1)Anep}/Hprt1⁺
• Genetic Background: FVB.129P2-Hprt1^{tm1(CUX1)Anep}

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:152682 )

♀ • at 5 weeks, ductal outgrowth is faster than in wild-type mice

♀ • however, at 3 months mammary gland development is normal

increased mammary gland tumor incidence ( J:152682 )

♀ • after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice

♀ • 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice

♀ • mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)

♀ • 3 mice with primary solid carcinoma exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:152682 )

♀

neoplasm

increased mammary gland tumor incidence ( J:152682 )

♀ • after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice

♀ • 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice

♀ • mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)

♀ • 3 mice with primary solid carcinoma exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:152682 )

♀

integument

abnormal branching of the mammary ductal tree ( J:152682 )

♀ • at 5 weeks, ductal outgrowth is faster than in wild-type mice

♀ • however, at 3 months mammary gland development is normal

increased mammary gland tumor incidence ( J:152682 )

♀ • after 2 years, 33% of female mice develop mammary carcinomas compared to 22% of wild-type mice

♀ • 12% of mice exhibit an average tumor latency of 20.5 months compared with 3% of wild-type mice

♀ • mammary tumors include solid carcinomas with or without papillary differentiation (29%) and adenosquamous carcinomas (71%)

♀ • 3 mice with primary solid carcinoma exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:152682 )

♀