Phenotypes associated with this allele

• Allele Symbol: Rag2^tm1Tgi
• Allele Name: targeted mutation 1, Masaru Taniguchi
• Allele ID: MGI:3687306
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rag2^tm1Tgi/Rag2^tm1Tgi	involves: 129S1/Sv * 129X1/SvJ	MGI:3690002

Genotype
MGI:3690002

hm1

• Allelic Composition: Rag2^tm1Tgi/Rag2^tm1Tgi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:113641 )

• thymocyte number is decreased 100-fold compared to wild-type and heterozygous mice

arrested B cell differentiation ( J:113641 )

• B cell development is blocked at B220+ IgM- pre-/pro-B cell stage

decreased double-positive T cell number ( J:113641 )

• only DN thymocytes are detected

arrested T cell differentiation ( J:113641 )

• only double-negative (DN) thymocytes are detected; developmental block occurs at CD44-CD25+ DN stage

decreased B cell number ( J:113641 )

• B cell number in bone marrow is decreased by ~half

abnormal Peyer's patch morphology ( J:113641 )

• only a fraction of cells in Peyer's patches express Rag2 amongst peripheral lymphoid organs; these T cells are of thymic origin

hematopoietic system

decreased thymocyte number ( J:113641 )

• thymocyte number is decreased 100-fold compared to wild-type and heterozygous mice

arrested B cell differentiation ( J:113641 )

• B cell development is blocked at B220+ IgM- pre-/pro-B cell stage

decreased double-positive T cell number ( J:113641 )

• only DN thymocytes are detected

arrested T cell differentiation ( J:113641 )

• only double-negative (DN) thymocytes are detected; developmental block occurs at CD44-CD25+ DN stage

decreased B cell number ( J:113641 )

• B cell number in bone marrow is decreased by ~half

endocrine/exocrine glands

decreased thymocyte number ( J:113641 )

• thymocyte number is decreased 100-fold compared to wild-type and heterozygous mice