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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dgkatm1Xpz
targeted mutation 1, Xiaoping Zhong
MGI:3687309
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dgkatm1Xpz/Dgkatm1Xpz involves: 129 * C57BL/6 MGI:3689989
cx2
 		Dgkatm1Xpz/Dgkatm1Xpz
Dgkztm1Gak/Dgkztm1Gak 		involves: 129 * 129X1/SvJ * C57BL/6 MGI:3689991


Genotype
MGI:3689989
hm1
Allelic
Composition		 Dgkatm1Xpz/Dgkatm1Xpz
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkatm1Xpz mutation (0 available); any Dgka mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell number ( J:113564 )
• in splenic and lymph node cells in mutants, T cells are hypoproliferative; anti-CD3 stimulation +/- CD28 costimulation induced hyperproliferation in contrast to wild-type cells which do not proliferate as strongly
increased interleukin-2 secretion ( J:113564 )
• after stimulation with anti-CD3 and CTLA-4, wild-type T cells become anergic and produce very little IL-2, but mutant cells produce more IL-2
abnormal lymphocyte anergy ( J:113564 )
• in mice injected with staphylococcal enterotoxin B (SEB), a superantigen, which makes Vbeta8+ T cells refractory to restimulation with the antigen, mutant T cells retain the ability to produce IL-2 and to proliferate upon SEB restimulation while wild-type cells show anergy and exhibit blunted proliferation and little cytokine response
• treatment with anti-CD3 and anti-CD28 which induces anergy in wild-type T cells does not affect mutant T cells which can still grow and produce IL-2

hematopoietic system
increased T cell number ( J:113564 )
• in splenic and lymph node cells in mutants, T cells are hypoproliferative; anti-CD3 stimulation +/- CD28 costimulation induced hyperproliferation in contrast to wild-type cells which do not proliferate as strongly




Genotype
MGI:3689991
cx2
Allelic
Composition		 Dgkatm1Xpz/Dgkatm1Xpz
Dgkztm1Gak/Dgkztm1Gak
Genetic
Background		 involves: 129 * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkatm1Xpz mutation (0 available); any Dgka mutation (87 available)
Dgkztm1Gak mutation (1 available); any Dgkz mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal thymocyte activation ( J:113564 )
• the few T cells present diplay constitutive expression of activation markers indicating inappropriate activation
abnormal T cell differentiation ( J:113564 )
• double mutants have substantial defects in thymocyte development; few CD4+ and CD8+ thymocytes and peripheral T cells are detected

immune system
abnormal thymocyte activation ( J:113564 )
• the few T cells present diplay constitutive expression of activation markers indicating inappropriate activation
abnormal T cell differentiation ( J:113564 )
• double mutants have substantial defects in thymocyte development; few CD4+ and CD8+ thymocytes and peripheral T cells are detected

endocrine/exocrine glands
abnormal thymocyte activation ( J:113564 )
• the few T cells present diplay constitutive expression of activation markers indicating inappropriate activation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory