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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr159tm1Fwa
targeted mutation 1, Frederick W Alt
MGI:3687497
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr159tm1Fwa/Rr159tm1Fwa involves: 129P2/OlaHsd * C57BL/6 MGI:3689746
ht2
 		Rr159tm1Fwa/Rr159+ involves: 129P2/OlaHsd * C57BL/6 MGI:3689744


Genotype
MGI:3689746
hm1
Allelic
Composition		 Rr159tm1Fwa/Rr159tm1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:113715 )
• increase in the percentage of lambda expressing B cells in spleen and bone marrow
• the ratio of newly generated to precursor B cells s significantly decreased
decreased B cell number ( J:113715 )
• total number of splenic B cells was reduced by 2-fold in spleen
• the number of kappa producing B cells in spleen was reduced dramatically; however the number of lambda producing B cells was increased by more than 5-fold

immune system
abnormal B cell differentiation ( J:113715 )
• increase in the percentage of lambda expressing B cells in spleen and bone marrow
• the ratio of newly generated to precursor B cells s significantly decreased
decreased B cell number ( J:113715 )
• total number of splenic B cells was reduced by 2-fold in spleen
• the number of kappa producing B cells in spleen was reduced dramatically; however the number of lambda producing B cells was increased by more than 5-fold




Genotype
MGI:3689744
ht2
Allelic
Composition		 Rr159tm1Fwa/Rr159+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell number ( J:113715 )
• a 2-fold increase in the percentage of lambda expressing B cells in peripheral blood and spleen compared with wild-type control: however number of splenic B cells wre not significantly decreased

immune system
increased B cell number ( J:113715 )
• a 2-fold increase in the percentage of lambda expressing B cells in peripheral blood and spleen compared with wild-type control: however number of splenic B cells wre not significantly decreased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory