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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-Edn3)1Takk
transgene insertion 1, Takahiro Kusinada
MGI:3687548
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mitfmi-vit/Mitfmi-vit
Tg(KRT14-Edn3)1Takk/? 		involves: C57BL/6 * C57BL/6J * DBA/2 MGI:3720190
tg2
 		Tg(KRT14-Edn3)1Takk/? B6.Cg-Tg(KRT14-Edn3)1Takk MGI:3720186
tg3
 		Tg(KRT14-Edn3)1Takk/? involves: C57BL/6 * DBA/2 MGI:3720188


Genotype
MGI:3720190
cx1
Allelic
Composition		 Mitfmi-vit/Mitfmi-vit
Tg(KRT14-Edn3)1Takk/?
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vit mutation (1 available); any Mitf mutation (74 available)
Tg(KRT14-Edn3)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:100658 )
• at 6 months fo age, mice lose pigmentation of dorsal hair
white spotting ( J:100658 )
• mice develop a ventral white spot similar to in Mitfmi-vit homozygotes
abnormal melanocyte morphology ( J:100658 )
• mice have an increased number of melanocytes but not as much as seen in Tg(KRT14-Edn3)1Takk mice
• melanocyte numbers decrease with age and mostly gone by 6 months

integument
abnormal coat/hair pigmentation ( J:100658 )
• at 6 months fo age, mice lose pigmentation of dorsal hair
white spotting ( J:100658 )
• mice develop a ventral white spot similar to in Mitfmi-vit homozygotes




Genotype
MGI:3720186
tg2
Allelic
Composition		 Tg(KRT14-Edn3)1Takk/?
Genetic
Background		 B6.Cg-Tg(KRT14-Edn3)1Takk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Edn3)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanocyte morphology ( J:104881 )
• melanocyte numbers are increased

neoplasm
increased thyroid tumor incidence ( J:104881 )
• incidence of thyroid tumors is increased at 6 months of age

endocrine/exocrine glands
increased thyroid tumor incidence ( J:104881 )
• incidence of thyroid tumors is increased at 6 months of age




Genotype
MGI:3720188
tg3
Allelic
Composition		 Tg(KRT14-Edn3)1Takk/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Edn3)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:100658 )
• mice have increased coat pigmentation and a ventral white spot at 2 months
abnormal skin pigmentation ( J:100658 )
• mice have increased pigment in their noses
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented
increased melanocyte number ( J:100658 )
• mice have an increased number of melanocytes

hearing/vestibular/ear
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented

craniofacial
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented

integument
darkened coat color ( J:100658 )
• mice have increased coat pigmentation and a ventral white spot at 2 months
abnormal skin pigmentation ( J:100658 )
• mice have increased pigment in their noses
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented

growth/size/body
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory