Phenotypes associated with this allele

• Allele Symbol: Nlgn1^tm1Bros
• Allele Name: targeted mutation 1, Nils Brose
• Allele ID: MGI:3687638
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlgn1^tm1Bros/Nlgn1^tm1Bros	Not Specified	MGI:3688627
cx2	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn2^tm1Bros/Nlgn2^tm1Bros	Not Specified	MGI:3688628
cx3	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros	Not Specified	MGI:3688630
cx4	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn2^tm1Bros/Nlgn2^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros	Not Specified	MGI:3688634

Genotype
MGI:3688627

hm1

• Allelic Composition: Nlgn1^tm1Bros/Nlgn1^tm1Bros
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS synaptic transmission ( J:113647 )

• NMDA-mediated synaptic transmission onto CA1 pyramidal cells is perturbed in acute hippocampal slices

Genotype
MGI:3688628

cx2

• Allelic Composition: Nlgn1^tm1Bros/Nlgn1^tm1Bros; Nlgn2^tm1Bros/Nlgn2^tm1Bros
• Genetic Background: Not Specified

behavior/neurological

abnormal parental behavior ( J:113647 )

• mice exhibit striking deficits in raising offspring

reproductive system

reduced fertility ( J:113647 )

• mice show drastically reduced reproduction rates

nervous system

abnormal CNS synaptic transmission ( J:113647 )

• in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed

Genotype
MGI:3688630

cx3

• Allelic Composition: Nlgn1^tm1Bros/Nlgn1^tm1Bros; Nlgn3^tm1Bros/Nlgn3^tm1Bros
• Genetic Background: Not Specified

behavior/neurological

abnormal parental behavior ( J:113647 )

♀ • mice exhibit striking deficits in raising offspring

nervous system

abnormal CNS synaptic transmission ( J:113647 )

♀ • in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed

reproductive system

reduced fertility ( J:113647 )

♀ • mice show drastically reduced reproduction rates

Genotype
MGI:3688634

cx4

• Allelic Composition: Nlgn1^tm1Bros/Nlgn1^tm1Bros; Nlgn2^tm1Bros/Nlgn2^tm1Bros; Nlgn3^tm1Bros/Nlgn3^tm1Bros
• Genetic Background: Not Specified

mortality/aging

neonatal lethality, complete penetrance ( J:113647 )

♀ • mice die within 24 hours after birth

growth/size/body

decreased body weight ( J:113647 )

♀ • mice have slightly reduced body weight compared to single or double knockout littermates

nervous system

abnormal nervous system development ( J:113647 )

♀ • ratio of glutamatergic vs GABAergic/glycinergic terminals is reduced in the PBC and inferior olive in mutants, but not in hypoglossal neurons

♀ • there is a 30% reduction in number of postsynaptic clusters containing GABA_AR alpha 1in the PBC

abnormal pre-Botzinger complex physiology ( J:113647 )

♀ • spontaneous postsynaptic currents from Pre-Botzinger complex (PBC) neurons are reduced in frequency and duration compared to single knockout animals

♀ • number of GABAergic and glycinergic sPSCs with lower and higher amplitudes are decreased by 85% and 95% respectively

♀ • frequency of GABAergic and glycinergic miniature PSCs (mPSCs) in PBC neurons is reduced by 80% compared to single knockout controls cells

♀ • frequency of spontaneous glutamatergic postsynaptic currents is decreased compared to single null PBC neurons

♀ • amplitudes of GABAergic/glycinergic evoked postsynaptic currents (ePSCs) are strongly decreased compared to single knockout neurons, while amplitudes in double knockout neurons is not significantly changed

respiratory system

abnormal respiration ( J:113647 )

♀ • mice show irregular and flat breathing movements