All Phenotypes Nlgn3<tm1Bros> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nlgn3^tm1Bros
targeted mutation 1, Nils Brose
MGI:3687640

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlgn3^tm1Bros/Nlgn3^tm1Bros	B6.Cg-Nlgn3^tm1Bros	MGI:4353654
cx2	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros	Not Specified	MGI:3688630
cx3	Nlgn2^tm1Bros/Nlgn2^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros	Not Specified	MGI:3688631
cx4	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn2^tm1Bros/Nlgn2^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros	Not Specified	MGI:3688634

Allelic Composition	Nlgn3^tm1Bros/Nlgn3^tm1Bros
Genetic Background	B6.Cg-Nlgn3^tm1Bros

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3^tm1Bros mutation (0 available); any Nlgn3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:151116 )

N	• mice exhibit normal sucrose preference and hippocampal memory function in a Morris water maze

impaired contextual conditioning behavior ( J:151116 )

• mice display decreased freezing in hippocampus-dependent contextual fear conditioning compared with wild-type mice

impaired cued conditioning behavior ( J:151116 )

• mice display decreased freezing in hippocampus-independent cued fear conditioning compared with wild-type mice

increased exploration in new environment ( J:151116 )

• in a hole board test, mice exhibit increased exploration compared with wild-type mice

increased locomotor activity ( J:151116 )

• mice exhibit increased motor activity, total distance traveled, and mean velocity compared with wild-type mice

• in an elevated plus maze, mice exhibit an increase in total distance traveled compared with wild-type mice

abnormal social investigation ( J:151116 )

• mice exhibit no preference for new stranger mouse unlike wild-type mice

decreased vocalization ( J:151116 )

• mice exhibit reduced ultrasound vocalization compared with wild-type mice

nervous system

nervous system phenotype ( J:151116 )

N	• mice exhibit normal prepulse inhibition and seizure propensity

decreased brain size ( J:151116 )

• brain volume is decreased compared to in wild-type mice

taste/olfaction

impaired olfaction ( J:151116 )

• mice exhibit increased latency to finding buried food compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:151116

Allelic Composition	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1^tm1Bros mutation (1 available); any Nlgn1 mutation (66 available)
Nlgn3^tm1Bros mutation (0 available); any Nlgn3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal parental behavior ( J:113647 )

• mice exhibit striking deficits in raising offspring

nervous system

abnormal CNS synaptic transmission ( J:113647 )

• in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed

reproductive system

reduced fertility ( J:113647 )

• mice show drastically reduced reproduction rates

Allelic Composition	Nlgn2^tm1Bros/Nlgn2^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn2^tm1Bros mutation (1 available); any Nlgn2 mutation (35 available)
Nlgn3^tm1Bros mutation (0 available); any Nlgn3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal parental behavior ( J:113647 )

• mice exhibit striking deficits in raising offspring

nervous system

abnormal CNS synaptic transmission ( J:113647 )

• in double nulls, high amplitude population of GABAergic and glycinergic sPSCs is decreased by <50%; numbers of sPSCs with lower amplitudes is moderately changed

reproductive system

reduced fertility ( J:113647 )

• mice show drastically reduced reproduction rates

Allelic Composition	Nlgn1^tm1Bros/Nlgn1^tm1Bros Nlgn2^tm1Bros/Nlgn2^tm1Bros Nlgn3^tm1Bros/Nlgn3^tm1Bros
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1^tm1Bros mutation (1 available); any Nlgn1 mutation (66 available)
Nlgn2^tm1Bros mutation (1 available); any Nlgn2 mutation (35 available)
Nlgn3^tm1Bros mutation (0 available); any Nlgn3 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:113647 )

• mice die within 24 hours after birth

growth/size/body

decreased body weight ( J:113647 )

• mice have slightly reduced body weight compared to single or double knockout littermates

nervous system

abnormal nervous system development ( J:113647 )

• ratio of glutamatergic vs GABAergic/glycinergic terminals is reduced in the PBC and inferior olive in mutants, but not in hypoglossal neurons

• there is a 30% reduction in number of postsynaptic clusters containing GABA_AR alpha 1in the PBC

abnormal pre-Botzinger complex physiology ( J:113647 )

• spontaneous postsynaptic currents from Pre-Botzinger complex (PBC) neurons are reduced in frequency and duration compared to single knockout animals

• number of GABAergic and glycinergic sPSCs with lower and higher amplitudes are decreased by 85% and 95% respectively

• frequency of GABAergic and glycinergic miniature PSCs (mPSCs) in PBC neurons is reduced by 80% compared to single knockout controls cells

• frequency of spontaneous glutamatergic postsynaptic currents is decreased compared to single null PBC neurons

• amplitudes of GABAergic/glycinergic evoked postsynaptic currents (ePSCs) are strongly decreased compared to single knockout neurons, while amplitudes in double knockout neurons is not significantly changed

respiratory system

abnormal respiration ( J:113647 )

• mice show irregular and flat breathing movements

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