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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mc4rI194F
I194F
MGI:3687867
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mc4rI194F/Mc4rI194F involves: C3HeB/FeJ * C57BL/6J MGI:3688523
ht2
 		Mc4rI194F/Mc4r+ involves: C3HeB/FeJ * C57BL/6J MGI:3688524


Genotype
MGI:3688523
hm1
Allelic
Composition		 Mc4rI194F/Mc4rI194F
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rI194F mutation (0 available); any Mc4r mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:113730 )
• mice display significantly higher body weight than wild-type littermates (females at week 11 are 138% of wild-type, at week 18 - 147%; males week 11- 116% at week 18, 123% of wild-type)
obese ( J:113730 )
increased susceptibility to weight gain ( J:113730 )
• observed weight gain is significantly greater than wild-type between 5 and 20 weeks of age; more pronounced in females than males




Genotype
MGI:3688524
ht2
Allelic
Composition		 Mc4rI194F/Mc4r+
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rI194F mutation (0 available); any Mc4r mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:113730 )
• higher than wild-type
increased susceptibility to weight gain ( J:113730 )
• observed weight gain is significantly greater than wild-type between 5 and 20 weeks of age; males and females show similar weight gain to homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory