Phenotypes associated with this allele

• Allele Symbol: Mc4r^Y302C
• Allele Name: Y302C
• Allele ID: MGI:3687868
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mc4r^Y302C/Mc4r^Y302C	involves: C3HeB/FeJ * C57BL/6J	MGI:3688526
ht2	Mc4r^Y302C/Mc4r^+	involves: C3HeB/FeJ * C57BL/6J	MGI:3688525

Genotype
MGI:3688526

hm1

• Allelic Composition: Mc4r^Y302C/Mc4r^Y302C
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:113730 )

• mice display significantly higher body weight than wild-type littermates (females at week 11 are 169% of wild-type, at week 18 - 173%; males week 11- 138% at week 18, 139% of wild-type)

obese ( J:113730 )

• obesity is more severe and develops earlier than in Mc4r^I194F homozygotes

increased susceptibility to weight gain ( J:113730 )

• observed weight gain is significantly greater than wild-type between 5 and 20 weeks of age; more pronounced in females than males

Genotype
MGI:3688525

ht2

• Allelic Composition: Mc4r^Y302C/Mc4r⁺
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

growth/size/body

increased body weight ( J:113730 )

• higher than wild-type

increased susceptibility to weight gain ( J:113730 )

• observed weight gain is significantly greater than wild-type between 5 and 20 weeks of age; more pronounced in females than males

• heterozygotes display intermediate weight gain, between homozygotes and wild-type