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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map2k6tm1Ina
targeted mutation 1, Izumi Nakashima
MGI:3687978
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map2k6tm1Ina/Map2k6tm1Ina involves: 129P2/OlaHsd MGI:3692605
cx2
Map2k6tm1Ina/Map2k6tm1Ina
Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3692612
cx3
Map2k6tm1Ina/Map2k6tm1Ina
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3692608


Genotype
MGI:3692605
hm1
Allelic
Composition
Map2k6tm1Ina/Map2k6tm1Ina
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6tm1Ina mutation (1 available); any Map2k6 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in homozygotes, a reduced percentage of TCRalphabetaint CD69lo caspase-active thymocytes is observed compared to wild-type mice, while no difference in caspase-activities in TCRalphabetaint is seen, compared to wild-type
• a lower percentage of TCRalphabetaintCD69lo cells show DNA fragmentation in the thymocyte cell population compared to wild-type




Genotype
MGI:3692612
cx2
Allelic
Composition
Map2k6tm1Ina/Map2k6tm1Ina
Tg(TcrLCMV)327Sdz/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6tm1Ina mutation (1 available); any Map2k6 mutation (42 available)
Tg(TcrLCMV)327Sdz mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• upon antigenic stimulation by injection of LCMV, caspase activation and DNA fragmentation in the TCRalphabetaint thymocyte population is reduced compared to Map2k6-sufficient transgenic mice, while levels in the TCRalphabetahi population are comparable
• upon antigenic stimulation by injection of LCMV, deletion of TCR CD4hiCD8hi cells is less efficient than in Map2k6-sufficient transgenic mice




Genotype
MGI:3692608
cx3
Allelic
Composition
Map2k6tm1Ina/Map2k6tm1Ina
Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6tm1Ina mutation (1 available); any Map2k6 mutation (42 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in males, an increased number of in TCRalphabetaintCD69lo CD4loCD8lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

hematopoietic system
• in males, an increased number of in TCRalphabetaintCD69lo CD4loCD8lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

cellular
• percentage of caspase-active cells in TCRalphabetaintCD69lo CD4hiCD8hi thymocyte population of males is lower than in Map2k6-sufficient transgene-expressing cells; as well, a smaller percentage of cells show DNA fragmentation

endocrine/exocrine glands
• in males, an increased number of in TCRalphabetaintCD69lo CD4loCD8lo thymocytes is observed compared to Map2k6-sufficient transgenic mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory