Phenotypes associated with this allele

• Allele Symbol: Pdcd1lg2^tm1Shr
• Allele Name: targeted mutation 1, Arlene H Sharpe
• Allele ID: MGI:3688152
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdcd1lg2^tm1Shr/Pdcd1lg2^tm1Shr	involves: 129/Sv * 129S4/SvJae	MGI:3688405

Genotype
MGI:3688405

hm1

• Allelic Composition: Pdcd1lg2^tm1Shr/Pdcd1lg2^tm1Shr
• Genetic Background: involves: 129/Sv * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG2a level ( J:113851 )

• 2 weeks post-infection, there is a 3.5-fold increase in parasite-specific IgG2a and total IgG2a compared to wild-type

increased IgM level ( J:113851 )

• 2 weeks post-infection, levels of parasite-specific IgM are enhanced compared to wild-type

increased susceptibility to parasitic infection ( J:113851 )

• by 9 weeks, lesions are significantly larger (12 mm) than in wild-type (9 mm) after subcutaneous inoculation with L. mexicana

• parasitic burden is increased by 10⁵-fold compared to wild-type

• mice show inflammatory infiltrates and multiple areas of necrosis similar to wild-type

hematopoietic system

increased IgG2a level ( J:113851 )

• 2 weeks post-infection, there is a 3.5-fold increase in parasite-specific IgG2a and total IgG2a compared to wild-type

increased IgM level ( J:113851 )

• 2 weeks post-infection, levels of parasite-specific IgM are enhanced compared to wild-type