Phenotypes associated with this allele

• Allele Symbol: Epha2^{Gt(KST085)Byg}
• Allele Name: gene trap KST085, BayGenomics
• Allele ID: MGI:3688255
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha2^Gt(KST085)Byg/Epha2^Gt(KST085)Byg	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3689377
ht2	Epha2^Gt(KST085)Byg/Epha2^+	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3689382

Genotype
MGI:3689377

hm1

• Allelic Composition: Epha2^{Gt(KST085)Byg}/Epha2^{Gt(KST085)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Development of progressive cataract in Epha2^{Gt(KST085)Byg}/Epha2^{Gt(KST085)Byg} mice

neoplasm

increased incidence of tumors by chemical induction ( J:112120 )

• following skin tumor initiation and promotion by DMBA and TPA tumor latency is decreased by 2 - 3 weeks, tumor incidence is increased 7 fold at 10 weeks after onset of treatment, and tumor growth is increased

• proliferation of skin tumor cells is increased

increased metastatic potential ( J:112120 )

• following a skin tumor initiation and promotion protocol using DMBA and TPA for 16 weeks the rate of malignant conversion of tumors is about twice that of wild-type mice

vision/eye

cortical cataract ( J:151310 )

• mice develop progressive cortical cataracts

• onset of lens opacity occurs as early as 1 month of age

• bilateral lens opacity is observed at 5 months unlike in wild-type mice

• mature cataracts with lens rupture occurs between 6 and 8 months

• by 12 months, over 80% of mice exhibit cataracts

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:112120 )

• following skin tumor initiation and promotion by DMBA and TPA tumor latency is decreased by 2 - 3 weeks, tumor incidence is increased 7 fold at 10 weeks after onset of treatment, and tumor growth is increased

• proliferation of skin tumor cells is increased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 6 multiple types		DOID:0110229	OMIM:116600	J:151310

Genotype
MGI:3689382

ht2

• Allelic Composition: Epha2^{Gt(KST085)Byg}/Epha2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

neoplasm

increased incidence of tumors by chemical induction ( J:112120 )

• following tumor initiation and promotion by DMBA and TPA increase in tumor incidence and growth, and decrease in tumor latency is intermediate between wild-type and homozygous mice

• proliferation of skin tumor cells is increased similar to increase in homozygous mice

• however, the rate of malignant conversion of tumors is similar to wild-type

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:112120 )

• following tumor initiation and promotion by DMBA and TPA increase in tumor incidence and growth, and decrease in tumor latency is intermediate between wild-type and homozygous mice

• proliferation of skin tumor cells is increased similar to increase in homozygous mice

• however, the rate of malignant conversion of tumors is similar to wild-type