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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igktm2Rsky
targeted mutation 2, Klaus Rajewsky
MGI:3688312
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ightm2Rsky/Igh+
Igktm2Rsky/Igk+ 		either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c) MGI:3689732
cx2
 		Ightm2Cgn/Igh+
Igktm2Rsky/Igk+ 		involves: 129P2/OlaHsd MGI:3851175
cx3
 		Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
Prkdcscid/Prkdcscid 		involves: 129P2/OlaHsd * BALB/c * C57BL/Ka MGI:3851176


Genotype
MGI:3689732
cx1
Allelic
Composition		 Ightm2Rsky/Igh+
Igktm2Rsky/Igk+
Genetic
Background		 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Rsky mutation (2 available); any Igh mutation (44 available)
Igktm2Rsky mutation (1 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:111431 )
• lack 3-83Ig+ mature B cells, although on an H2d background some 3-83Ig+ immature B cells are detected in the bone marrow

hematopoietic system
abnormal B cell differentiation ( J:111431 )
• lack 3-83Ig+ mature B cells, although on an H2d background some 3-83Ig+ immature B cells are detected in the bone marrow




Genotype
MGI:3851175
cx2
Allelic
Composition		 Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cgn mutation (1 available); any Igh mutation (44 available)
Igktm2Rsky mutation (1 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:150435 )
• B cells have about a 2-fold increase in class switch recombination to IgG1

immune system
abnormal class switch recombination ( J:150435 )
• B cells have about a 2-fold increase in class switch recombination to IgG1




Genotype
MGI:3851176
cx3
Allelic
Composition		 Ightm2Cgn/Igh+
Igktm2Rsky/Igk+
Prkdcscid/Prkdcscid
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/Ka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cgn mutation (1 available); any Igh mutation (44 available)
Igktm2Rsky mutation (1 available); any Igk mutation (26 available)
Prkdcscid mutation (179 available); any Prkdc mutation (418 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:150435 )
• B cells show defects in CSR to IgG1 and IgG3 ranging from 30%?70% of controls

immune system
abnormal class switch recombination ( J:150435 )
• B cells show defects in CSR to IgG1 and IgG3 ranging from 30%?70% of controls




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory