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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdx1tm1Egs
targeted mutation 1, Edouard G Stanley
MGI:3688420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Pdx1tm1Egs/Pdx1+ involves: 129S1/Sv MGI:3695580
cx2
 		Pdx1tm1Egs/Pdx1+
Stk11tm1.1Gne/Stk11tm1.1Gne 		involves: 129S1/Sv * C57BL/6N MGI:5484546


Genotype
MGI:3695580
ht1
Allelic
Composition		 Pdx1tm1Egs/Pdx1+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Egs mutation (1 available); any Pdx1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:110137 )
• mice are phenotypically indistinguishable from wild-type and expression of the reporter faithfully reproduces the known expression pattern of Pdx1




Genotype
MGI:5484546
cx2
Allelic
Composition		 Pdx1tm1Egs/Pdx1+
Stk11tm1.1Gne/Stk11tm1.1Gne
Genetic
Background		 involves: 129S1/Sv * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1tm1Egs mutation (1 available); any Pdx1 mutation (35 available)
Stk11tm1.1Gne mutation (0 available); any Stk11 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
pancreas cyst ( J:195229 )
• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1
• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity

cellular
increased cell proliferation ( J:195229 )
• increased epithelial cell proliferation accompanies pancreatic cyst formation in 1NMPP1-treated pancreatic explants

growth/size/body
pancreas cyst ( J:195229 )
• dynamic and AMPK-independent cyst formation in late, but not early, stage pancreas explants treated with 1NMPP1
• pancreatic cysts induced by treatment with 1NMPP1 evolve into precancerous-like lesions without loss of cell polarity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory