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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apctm2.1Rak
targeted mutation 2.1, Raju Kucherlapati
MGI:3688437
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Apctm2.1Rak/Apc+ involves: 129/Sv * C57BL/6J * SJL MGI:3688733
ht2
 		Apctm2Rak/Apctm2.1Rak involves: 129/Sv * C57BL/6J * SJL MGI:3688734


Genotype
MGI:3688733
ht1
Allelic
Composition		 Apctm2.1Rak/Apc+
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Rak mutation (1 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Multiple intestinal neoplasia in Apctm2.1Rak/Apc+ mice

mortality/aging
premature death ( J:114152 )
• median lifespan is 5 months

behavior/neurological
abnormal nursing ( J:114152 )
• females often become too unhealthy to successfully nurse their pups

neoplasm
increased gastrointestinal tumor incidence ( J:114152 )
• at time of death, mice display average of 100 intestinal tumors

cardiovascular system
rectal hemorrhage ( J:114152 )
• mice display progressive signs of rectal bleeding

digestive/alimentary system
rectal hemorrhage ( J:114152 )
• mice display progressive signs of rectal bleeding
increased gastrointestinal tumor incidence ( J:114152 )
• at time of death, mice display average of 100 intestinal tumors

hematopoietic system
anemia ( J:114152 )
• mice display progressive signs of anemia up to time of death




Genotype
MGI:3688734
ht2
Allelic
Composition		 Apctm2Rak/Apctm2.1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm2.1Rak mutation (1 available); any Apc mutation (158 available)
Apctm2Rak mutation (1 available); any Apc mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:114152 )
• mice are healthy and viable




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory