Analysis Tools|
Allele Symbol Allele Name Allele ID |
Spi1tm2Dgt targeted mutation 2, Daniel G Tenen MGI:3688438 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• purified GMPs from homozygous mice transfected with retroviral transduction of cre form only colonies composed of myeloblasts
• cultured CMPs form megakaryocyte/erythroid colonies as well as myeloblast colonies that appear to replace GM-related colonies that form when normal CMPs are cultured
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice have normal numbers of pre-B cells and mature B cells in the bone marrow
• B cells from the spleen show significant proliferative responses to mitogenic agents
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2-3 weeks after induction of cre expression with pI-pC, number of HSCs in bone marrow is decreased with loss of CMPs, GMPs and mature myeloid cells while MEPs are increased; mature granulocytes have disappeared
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2-3 weeks after induction of cre expression with pI-pC, number of HSCs in bone marrow is decreased with loss of CMPs, GMPs and mature myeloid cells while MEPs are increased
• by 6 weeks, numbers of CLPs, CMPs, and GMPs begin to recover
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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