cardiovascular system
• mutants are more susceptible to inducible ventricular arrhythmias and develop spontaneous arrhythmias but show no differences in conduction time, sinus recovery time, atrial and AV node refractory period, AV Wenckebach cycle time, heart rate, P-R interval, QRS duration, or QTc
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• isolated myocytes exhibit diminished intercellular transfer of Lucifer yellow dye and increased transfer of neurobiotin, indicating altered cell-to-cell communication
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