Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-PRKAG2)#Rro
• Allele Name: transgene insertion #, Robert Roberts
• Allele ID: MGI:3688893
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-PRKAG2)#Rro/0	involves: FVB	MGI:3689005

Genotype
MGI:3689005

tg1

• Allelic Composition: Tg(Myh6-PRKAG2)#Rro/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:108102 )

• myocytes exhibit multiple nuclei with great variation in size, indicating hypertrophy, but do not show an accumulation of glycogen

enlarged heart ( J:108102 )

increased heart weight ( J:108102 )

• heart weight is increased but not as much as in Tg(Myh6-PRKAG2*R302Q)#Rro mutants

cardiac hypertrophy ( J:108102 )

• hypertrophic cardiomyocytes

decreased heart ventricle muscle contractility ( J:108102 )

• posterior wall thickness at 2 months of age is increased and exhibit an increase in end-diastolic diameter and end-systolic diameter with decreased systolic function, however to a lesser extent than that seen in Tg(Myh6-PRKAG2*R302Q)#Rro mutants, however exhibit normal impulse conducting system conduction

increased heart rate ( J:108102 )

• atrial premature beats and/or tachycardia are observed spontaneously or after atrial electrical stimulation in 27% (3 of 11) of mutants, however ventricular electrical stimulation does not induce ventricular arrhythmias

muscle

abnormal myocardial fiber morphology ( J:108102 )

• myocytes exhibit multiple nuclei with great variation in size, indicating hypertrophy, but do not show an accumulation of glycogen

decreased heart ventricle muscle contractility ( J:108102 )

• posterior wall thickness at 2 months of age is increased and exhibit an increase in end-diastolic diameter and end-systolic diameter with decreased systolic function, however to a lesser extent than that seen in Tg(Myh6-PRKAG2*R302Q)#Rro mutants, however exhibit normal impulse conducting system conduction

growth/size/body

enlarged heart ( J:108102 )

increased heart weight ( J:108102 )

• heart weight is increased but not as much as in Tg(Myh6-PRKAG2*R302Q)#Rro mutants

cardiac hypertrophy ( J:108102 )

• hypertrophic cardiomyocytes