Phenotypes associated with this allele

• Allele Symbol: Soa^a
• Allele Name: sucrose octaacetate aversion, a variant
• Allele ID: MGI:3689003
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Soa^a/Soa^a	SWR	MGI:3798650
ht2	Soa^a/Soa^c	C3FeJ.SW-Soa^a/Soa^c	MGI:3798789

Genotype
MGI:3798650

hm1

• Allelic Composition: Soa^a/Soa^a
• Genetic Background: SWR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal taste sensitivity ( J:44684 )

• Background Sensitivity: mice have a higher aversion for drinking water containing calcium hydroxide than the C3HeB strain or SWR mice heterozygote for the Soa^a allele

abnormal bitter taste sensitivity ( J:6574 , J:44684 )

• mice demonstrate a strong aversion to the bitter tasting compound sucrose octaacetate (SOA) when present in drinking water at 100 micromolar concentrations compared to thirty other in-bred strains that had no aversion to SOA at this concentration (J:6574)

• mice avoid drinking water containing 0.1 mM of the bitter acetylated sugar sucrose octaacetate (SOA) compared to C3HeB/Fe mice that do not show any aversion to SOA at this concentration (J:44684)

• strong taste aversion to SOA occurs at concentrations as low as 3 micromolar while C3HeB mice only display moderate taste aversion at 1 mM (J:44684)

• mice also have strong taste aversions to drinking water containing 0.01 to 1 mM of brucine, strychnine, 6-n-propyl-2 thiouracil or 0.1mM denatonium benzoate while C3Heb mice do not display taste aversions at these concentrations (J:44684)

• mice exhibit taste aversion to quinine compounds at low concentrations (0.03 mM-0.1 mM) while control C3HeB mice only exhibit taste aversions at higher concentrations (0.3 mM-1 mM) (J:44684)

• Background Sensitivity: aversion to water containing low concentrations of caffeine, cyclohexamide, and thiamine occurs in SWR mice while SWR mice heterozygote for the Soa^a allele do not have aversion for these compounds at low concentrations (J:44684)

Genotype
MGI:3798789

ht2

• Allelic Composition: Soa^a/Soa^c
• Genetic Background: C3FeJ.SW-Soa^a/Soa^c

taste/olfaction

abnormal bitter taste sensitivity ( J:44684 )

• mice carrying the Soa^a allele are phenotyped by their taste aversion to drinking water containing 0.1 mM of the bitter acetylated sugar sucrose octaacetate (SOA)

• strong taste aversion to SOA occurs at concentrations as low as 3 micromolar while C3HeB mice only display moderate taste aversion at 1mM

• mice also have strong taste aversions to drinking water containing 0.01 to 1 mM of brucine, strychnine, 6-n-propyl-2 thiouracil or 0.1 mM denatonium benzoate while C3Heb mice do not display taste aversions at these concentrations

• mice exhibit taste aversion to quinine compounds at low concentrations (0.03 mM-0.1 mM) while control C3HeB mice only exhibit taste aversions at higher concentrations (0.3 mM-1 mM)

• mice do not have taste aversion for low concentrations of caffeine, cyclohexamide, and thiamine unlike the background SWR strain that does exhibit taste aversions