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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Adra1a)A1A4Rmgr
transgene insertion A1A4, Robert M Graham
MGI:3689095
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Adra1a)A1A4Rmgr/0 FVB/N-Tg(Myh6-Adra1a)A1A4Rmgr MGI:3689111


Genotype
MGI:3689111
tg1
Allelic
Composition
Tg(Myh6-Adra1a)A1A4Rmgr/0
Genetic
Background
FVB/N-Tg(Myh6-Adra1a)A1A4Rmgr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 34 of 135 die at a mean age of 224 days with a cumulative mortality of 25%
• premature death is sudden with no signs of heart failure

cardiovascular system
• observe degeneration of cardiomyocytes within larger fibrotic areas of the ventricles at 22 months of age
• develop progressive cardiac fibrosis with age
• although at young ages exhibit enhanced left ventricle contractility, mutants show a loss in hypercontractility as they age (J:108867)
• exhibit an increase in left ventricular (LV) dP/dt max and the ratio of dP/dt max to dP/dt min (J:108879)

muscle
• observe degeneration of cardiomyocytes within larger fibrotic areas of the ventricles at 22 months of age
• although at young ages exhibit enhanced left ventricle contractility, mutants show a loss in hypercontractility as they age (J:108867)
• exhibit an increase in left ventricular (LV) dP/dt max and the ratio of dP/dt max to dP/dt min (J:108879)
• exhibit an increase in apoptotic cells in the ventricles at 12 months of age

cellular
• exhibit an increase in apoptotic cells in the ventricles at 12 months of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory