Phenotypes associated with this allele

• Allele Symbol: Rab27a^cct
• Allele Name: concrete
• Allele ID: MGI:3689096
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab27a^cct/Rab27a^cct	C57BL/6-Rab27a^cct	MGI:3689102

Genotype
MGI:3689102

hm1

• Allelic Composition: Rab27a^cct/Rab27a^cct
• Genetic Background: C57BL/6-Rab27a^cct

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

hypopigmentation ( J:114299 )

immune system

immune system phenotype ( J:114299 )

N • neutrophils of homozygous mutant mice efficiently phagocytose Texas red-conjugated, opsonized zymosan particles

N • during phagocytosis, myeloperoxidase is delivered efficiently to the phagosomes of homozygous mutant neutrophils

abnormal neutrophil physiology ( J:114299 )

• plasma myeloperoxidase (MPO) elevation, which results from MPO secretion by neutrophils, following intraperitoneal injection of bacterial lipopolysaccharide (LPS) is greatly attenuated in homozygous mutant mice, although circulating neutrophil numbers and baseline plasma MPO concentrations do not differ between control and mutant mice

hematopoietic system

abnormal neutrophil physiology ( J:114299 )

• plasma myeloperoxidase (MPO) elevation, which results from MPO secretion by neutrophils, following intraperitoneal injection of bacterial lipopolysaccharide (LPS) is greatly attenuated in homozygous mutant mice, although circulating neutrophil numbers and baseline plasma MPO concentrations do not differ between control and mutant mice