Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Ccl21b)2Cys
• Allele Name: transgene insertion 2, Jason G Cyster
• Allele ID: MGI:3689181
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ins2-Ccl19)2Cys/0 Tg(Ins2-Ccl21b)2Cys/0	involves: C57BL/6 * DBA/2	MGI:3689356
tg2	Tg(Ins2-Ccl21b)2Cys/0	involves: C57BL/6 * DBA/2	MGI:3689351

Genotype
MGI:3689356

cx1

• Allelic Composition: Tg(Ins2-Ccl19)2Cys/0; Tg(Ins2-Ccl21b)2Cys/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:77238 )

Genotype
MGI:3689351

tg2

• Allelic Composition: Tg(Ins2-Ccl21b)2Cys/0
• Genetic Background: involves: C57BL/6 * DBA/2

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:77238 )

• high frequency of infiltrates of all sizes form in young mice

• pancreatic islets show infiltration by large numbers of CD4+ and CD8+ T cells, IgD+ B cells and CDIIc+ dendritic cells (DCs)

• gp38+, BP3+, and ER-TR7+ stromal cell networks form in infiltrates, with higher efficiency than in Ccl19 transgenic mice

• DCs and T cells localize close to chemokine-expressing islet cells

• infiltrates display an invasive phenotype with individual T cells frequently seen in the islet cell mass

immune system

abnormal lymph organ development ( J:77238 )

• development of high endothelial venules (HEVs) which are characterized by thick endothelium and addressin expression in the lymphoid tissue with higher efficiency than in Ccl19 transgenic mice is seen

• 3 week treatment with lymphotoxin beta receptor (LTBR) induces loss of HEVs and stromal cells