Phenotypes associated with this allele

• Allele Symbol: Akr1b1^tm1Tona
• Allele Name: targeted mutation 1, Toshimasa Onaya
• Allele ID: MGI:3689185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akr1b1^tm1Tona/Akr1b1^tm1Tona	involves: 129S/SvEv * C57BL/6	MGI:3689737

Genotype
MGI:3689737

hm1

• Allelic Composition: Akr1b1^tm1Tona/Akr1b1^tm1Tona
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:114187 )

• after 48 hours of water deprivation, body weight decreased significantly compared to wild-type

homeostasis/metabolism

increased circulating calcium level ( J:114187 )

• serum calcium concentration is higher than in wild-type

increased circulating magnesium level ( J:114187 )

• serum magnesium concentration is higher than in wild-type

increased urine calcium level ( J:114187 )

• urinary excretion of calcium is significantly greater than in wild-type

decreased urine osmolality ( J:114187 )

• urine osmolality is decreased 2.5-fold; osmolality increased significantly after water deprivation but values are significantly lower (1068 mOsm/kg water) than in wild-type (2517 mOsm/kg water)

• urine osmolality remains lower in mutants vs wild-type, in response to vasopressin treatment, although osmolality in both increases significantly

renal/urinary system

increased urine calcium level ( J:114187 )

• urinary excretion of calcium is significantly greater than in wild-type

decreased urine osmolality ( J:114187 )

• urine osmolality is decreased 2.5-fold; osmolality increased significantly after water deprivation but values are significantly lower (1068 mOsm/kg water) than in wild-type (2517 mOsm/kg water)

• urine osmolality remains lower in mutants vs wild-type, in response to vasopressin treatment, although osmolality in both increases significantly

polyuria ( J:114187 )

• urine output is increased