Phenotypes associated with this allele

• Allele Symbol: Tnf^R8H
• Allele Name: R8H
• Allele ID: MGI:3689190
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnf^R8H/Tnf^R8H	involves: I/St	MGI:3689866

Genotype
MGI:3689866

hm1

• Allelic Composition: Tnf^R8H/Tnf^R8H
• Genetic Background: involves: I/St

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:114302 )

• mutants have mean survival time of 23.5 days after H37Rv infection, compared to strains not carrying this variant (45-63 days survival)

immune system

increased susceptibility to bacterial infection ( J:114302 )

• mice with this variant of Tnf are more susceptible to infection by a virulent human M. tuberculosis isolate, H37Rv, than other strains, as show by decreased survival time after infection