Phenotypes associated with this allele

• Allele Symbol: Trpc3^Mwk
• Allele Name: moonwalker
• Allele ID: MGI:3689326
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc3^Mwk/Trpc3^Mwk	involves: BALB/cAnN * C3H/HeH	MGI:3839132
ht2	Trpc3^Mwk/Trpc3^+	involves: BALB/cAnN * C3H/HeH	MGI:3839134

Genotype
MGI:3839132

hm1

• Allelic Composition: Trpc3^Mwk/Trpc3^Mwk
• Genetic Background: involves: BALB/cAnN * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:148340 )

• homozygotes are not viable

• no time of death is specified

Genotype
MGI:3839134

ht2

• Allelic Composition: Trpc3^Mwk/Trpc3⁺
• Genetic Background: involves: BALB/cAnN * C3H/HeH

Ataxic behavior in Trpc3^Mwk/Trpc3⁺ mice

growth/size/body

decreased body size ( J:148340 )

• about 60% of the size of controls

behavior/neurological

impaired balance ( J:148340 )

• severely impaired ability to maintain balance and walk along a stationary beam

abnormal gait ( J:148340 )

• starting from 3 weeks of age onward

• retropulsion

• side to side meandering gait

• broad gait width

• shuffling gait, nonuniform alternating footstep pattern

nervous system

abnormal Purkinje cell morphology ( J:148340 )

• in an otherwise normal cerebellum

abnormal Purkinje cell dendrite morphology ( J:148340 )

• dendritic arbors are less elaborate with fewer branches in 3 week old mice

• shorter dendrites

decreased Purkinje cell number ( J:148340 )

• slow, progressive loss of Purkinje cells starting at 4 months of age

• extensive loss of Purkinje cells by 6 months, particularly in the lateral cerebellar lobes

abnormal nervous system electrophysiology ( J:148340 )

• inward current due to application of high concentrations (20 microM) of (S)-3,5-dihydroxyphenylglycine with smaller spikes and faster interspike intervals or no inward current at all

• lower concentrations (5 microM) always result in an inward current but not necessarily in controls