Phenotypes associated with this allele

• Allele Symbol: Tg(B19-RNAi:Il3)241Ckn
• Allele Name: transgene insertion 241, Debra A Cockayne
• Allele ID: MGI:3689387
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(B19-RNAi:Il3)241Ckn/?	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:3693964

Genotype
MGI:3693964

tg1

• Allelic Composition: Tg(B19-RNAi:Il3)241Ckn/?
• Genetic Background: involves: BALB/cJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107618 )

• incomplete penetrance of phenotypes results in some mice developing either a fatal neurological disorder or fatal pre-B cell lymphproliferative syndrome by 3-6 months of age

immune system

enlarged spleen ( J:107618 )

• observed in mice with lymphoproliferative syndrome

• contains cellular infiltrate of immature-appearing, mitotically active round cells

abnormal B cell differentiation ( J:107618 )

• evidence of lymphoproliferative syndrome is observed by 3 months of age in spleen and lymph nodes

• lymphoproliferation is characterized by cellular infiltrate populated primarily by pre-B cells (B220+/sIgM-)

• bone marrow, thymus, spinal cord and skeletal muscle fibers develop cellular infiltrate late in the disease process

increased pre-B cell number ( J:107618 )

• 90% of cells in lymph node express B220+/sIgM- surface antigens, however, absolute number of peripheral T cells is unchanged

enlarged lymph nodes ( J:107618 )

• peripheral adenopathy

• observed in mice with lymphoproliferative syndrome

• contain cellular infiltrate of immature-appearing, mitotically active round cells

decreased interleukin-3 secretion ( J:107618 )

• ConA-stimulated splenocytes from asymptomatic transgenic mice produce significantly less IL3 than stimulated controls

behavior/neurological

ataxia ( J:107618 )

• observed in mice with neurological disorder between 3-6 months of age

hindlimb paralysis ( J:107618 )

• occurs in some mice in late stages of lymphoproliferative syndrome

circling ( J:107618 )

• first observed in mice with neurological disorder between 3-6 months of age, progressing to ataxia, then wasting within 2-4 weeks

hematopoietic system

enlarged spleen ( J:107618 )

• observed in mice with lymphoproliferative syndrome

• contains cellular infiltrate of immature-appearing, mitotically active round cells

abnormal B cell differentiation ( J:107618 )

• evidence of lymphoproliferative syndrome is observed by 3 months of age in spleen and lymph nodes

• lymphoproliferation is characterized by cellular infiltrate populated primarily by pre-B cells (B220+/sIgM-)

• bone marrow, thymus, spinal cord and skeletal muscle fibers develop cellular infiltrate late in the disease process

increased pre-B cell number ( J:107618 )

• 90% of cells in lymph node express B220+/sIgM- surface antigens, however, absolute number of peripheral T cells is unchanged

growth/size/body

cachexia ( J:107618 )

• observed in mice with neurological disorder

enlarged spleen ( J:107618 )

• observed in mice with lymphoproliferative syndrome

• contains cellular infiltrate of immature-appearing, mitotically active round cells