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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chattm1(cre)Lowl
targeted mutation 1, Bradford B Lowell
MGI:3689420
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Chattm1(cre)Lowl/Chat+ involves: 129S6/SvEvTac * C57BL/6 MGI:3689725
cn2
 		Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Chattm1(cre)Lowl/Chat+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:5524149
cn3
 		Mc4rtm1Lowl/Mc4rtm1Lowl
Chattm1(cre)Lowl/Chat+ 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:5484740
cn4
 		Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NCr MGI:5484737


Genotype
MGI:3689725
ht1
Allelic
Composition		 Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:114556 )
• heterozygotes are viable and fertile; cre recombinase activity is detected in all cholinergic neurons




Genotype
MGI:5524149
cn2
Allelic
Composition		 Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brsk2tm2.1Jrs mutation (1 available); any Brsk2 mutation (37 available)
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:201695 )
N
• type Ia proprioceptive sensory neuron projections grow normally to the ventral horn




Genotype
MGI:5484740
cn3
Allelic
Composition		 Mc4rtm1Lowl/Mc4rtm1Lowl
Chattm1(cre)Lowl/Chat+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (58 available)
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypertension ( J:193452 )
• develop obesity induced hypertension but only during active period

homeostasis/metabolism
increased circulating insulin level ( J:193452 )
• higher plasma insulin levels




Genotype
MGI:5484737
cn4
Allelic
Composition		 Mc4rtm2Lowl/Mc4rtm2Lowl
Chattm1(cre)Lowl/Chat+
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm1(cre)Lowl mutation (1 available); any Chat mutation (58 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Mc4rtm2Lowl mutation (0 available); any Mc4r mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:193452 )
N
• biophysical properties of cholinergic neurons are normal
abnormal nervous system electrophysiology ( J:193452 )
• melanotan II fails to hyperpolarize membrane potentials of all dorsal motor nucleus vagal cholinergic neurons
• similar results with Mc4r agonist THIQ




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory