Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Nr5a1-cre)2Klp transgene insertion 2, Keith L Parker MGI:3689423 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• few mutants are recovered after birth, however mutants are recovered at E18.5, indicating perinatal lethality
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• testes are frequently hemorrhagic at E18.5
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• reduction in steroid-producing cells in the adrenal glands at E18.5
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• reduction in adrenal cortex
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• small adrenal glands are seen just before birth (E18.5)
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• reduction in steroid-producing cells in the testis at E18.5
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• small testes at E18.5
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• testes are frequently hemorrhagic at E18.5
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• testes are frequently hemorrhagic at E18.5
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• reduction in steroid-producing cells in the testis at E18.5
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• small testes at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• phenotypes observed in testes and ovaries at 6 weeks of age are recoverable by 3 and 6 months of age
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• few sperm are seen within the epididymis at 6 weeks of age
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• observe areas of spermatocyte loss from the testis cords at 6 weeks of age
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• 6-8 week old females have decreased follicle development
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• 6-8 week old females have reduced numbers of theca cells in the maturing follicles of the ovaries, although a thin, broken theca interna is seen in the ovary
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• 6-8 week old females have small ovaries
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• fewer steroid-producing cells are seen at E12.5-E14.5 in the testis
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• testis cord formation is delayed at E12.5-E14.5
• observe areas of spermatocyte loss from the testis cords at 6 weeks of age
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• reduction in number of adult Leydig cells at 6 weeks of age
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• testes are smaller at 6 weeks of age but by 10 weeks they appear normal sized
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• 6-8 week old females have underdeveloped uteri
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• delay in fertility, however by 3 to 6 months of age, mutants become fertile
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• 6-8 week old females show no evidence of ovlulation
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• 6-8 week old females exhibit lower estradiol levels
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• 75% of mutants exhibit low testosterone levels in the testes at 6 weeks of age, however by 10 weeks, levels are higher
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• 6-8 week old females have decreased follicle development
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• 6-8 week old females have reduced numbers of theca cells in the maturing follicles of the ovaries, although a thin, broken theca interna is seen in the ovary
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• 6-8 week old females have small ovaries
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• fewer steroid-producing cells are seen at E12.5-E14.5 in the testis
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• testis cord formation is delayed at E12.5-E14.5
• observe areas of spermatocyte loss from the testis cords at 6 weeks of age
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• reduction in number of adult Leydig cells at 6 weeks of age
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• testes are smaller at 6 weeks of age but by 10 weeks they appear normal sized
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• few sperm are seen within the epididymis at 6 weeks of age
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• observe areas of spermatocyte loss from the testis cords at 6 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
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• follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized
• all follicles masculinized at age 4 months
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• medullar follicles organized into pseudo-tubular structures (masculinization: transdifferentiation of granulosa cells into Sertoli cells) at age 8 weeks
• remodeling (masculinization) of cortical follicles started by age 8 weeks, though follicles still organized
• all follicles masculinized at age 4 months
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| N |
• normal apoptosis in ovaries at ages P20 and 8 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adrenal glands exhibit a decrease in stem/precursor cells compared with wild-type mice
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• the number of adrenocortical cells is decreased while their size is increased compared to in wild-type mice
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• at P5
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• at E16.5 and P5, adrenal gland cells exhibit reduced proliferation compared with wild-type cells
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• at P21
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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