Phenotypes associated with this allele

• Allele Symbol: Pgr^tm1.1Mlia
• Allele Name: targeted mutation 1.1, M Luisa Iruela-Arispe
• Allele ID: MGI:3689426
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgr^tm1.1Mlia/Pgr^tm1.1Mlia	involves: 129 * C57BL/6J	MGI:3689573
cn2	Pgr^tm1.1Mlia/Pgr^tm1.1Mlia Tg(Cdh5-cre)7Mlia/0	involves: 129X1/SvJ * FVB/N	MGI:5566877

Genotype
MGI:3689573

hm1

• Allelic Composition: Pgr^tm1.1Mlia/Pgr^tm1.1Mlia
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:114465 )

• homozygous females are fully viable, fertile and phenotypically normal

Genotype
MGI:5566877

cn2

• Allelic Composition: Pgr^tm1.1Mlia/Pgr^tm1.1Mlia; Tg(Cdh5-cre)7Mlia/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

reproductive system

impaired embryo implantation ( J:205553 )

♀ • 43% reduction in the number of implantation sites compared to controls

abnormal uterus physiology ( J:205553 )

♀ • change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced

♀ • increase in albumin extravasation during pregnancy is significantly reduced

cardiovascular system

abnormal vascular permeability ( J:205553 )

♀ • changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced