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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pgrtm1.2Mlia
targeted mutation 1.2, M Luisa Iruela-Arispe
MGI:3689427
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pgrtm1.2Mlia/Pgrtm1.2Mlia involves: 129 * C57BL/6J MGI:3689574
hm2
Pgrtm1.2Mlia/Pgrtm1.2Mlia involves: 129X1/SvJ MGI:5566875


Genotype
MGI:3689574
hm1
Allelic
Composition
Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.2Mlia mutation (0 available); any Pgr mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• females examined for egg presence by flushing or histology are found to be anovulatory after exposure to superovulation hormonal regiments
• homozygotes are sterile while heterozygous females and heterozygous males show normal fertility




Genotype
MGI:5566875
hm2
Allelic
Composition
Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.2Mlia mutation (0 available); any Pgr mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• expression analysis indicates a defect in uterine differentiation
• impairment in the increase in uterine weight and change in vascular permeability in response to P4





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory