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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2Rsky
targeted mutation 2, Klaus Rajewsky
MGI:3689719
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ightm2Rsky/Igh+
Igktm1Rsky/Igk+ 		either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c) MGI:3689731
cx2
 		Ightm2Rsky/Igh+
Igktm2Rsky/Igk+ 		either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c) MGI:3689732


Genotype
MGI:3689731
cx1
Allelic
Composition		 Ightm2Rsky/Igh+
Igktm1Rsky/Igk+
Genetic
Background		 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Rsky mutation (2 available); any Igh mutation (44 available)
Igktm1Rsky mutation (1 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:111431 )
• lack 3-83Ig+ mature B cells, although on an H2d background some 3-83Ig+ immature B cells are detected in the bone marrow
• about and 8-fold and 15-fold increase in the frequency and absolute number of lambda expressing splenic B cells, respectively, compared to wild-type mice
• however, total B cell numbers are similar to wild-type

hematopoietic system
abnormal B cell differentiation ( J:111431 )
• lack 3-83Ig+ mature B cells, although on an H2d background some 3-83Ig+ immature B cells are detected in the bone marrow
• about and 8-fold and 15-fold increase in the frequency and absolute number of lambda expressing splenic B cells, respectively, compared to wild-type mice
• however, total B cell numbers are similar to wild-type




Genotype
MGI:3689732
cx2
Allelic
Composition		 Ightm2Rsky/Igh+
Igktm2Rsky/Igk+
Genetic
Background		 either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Rsky mutation (2 available); any Igh mutation (44 available)
Igktm2Rsky mutation (1 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:111431 )
• lack 3-83Ig+ mature B cells, although on an H2d background some 3-83Ig+ immature B cells are detected in the bone marrow

hematopoietic system
abnormal B cell differentiation ( J:111431 )
• lack 3-83Ig+ mature B cells, although on an H2d background some 3-83Ig+ immature B cells are detected in the bone marrow




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory