Phenotypes associated with this allele

• Allele Symbol: Il5^tm2Anjm
• Allele Name: targeted mutation 2, Andrew NJ McKenzie
• Allele ID: MGI:3689812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il5^tm2Anjm/Il5^tm2Anjm Il9^tm1Anjm/Il9^tm1Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3689876

Genotype
MGI:3689876

cx1

• Allelic Composition: Il5^tm2Anjm/Il5^tm2Anjm; Il9^tm1Anjm/Il9^tm1Anjm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:113543 )

• eosinophilia is delayed compared to wild-type, but once induced, correlates with worm clearance

abnormal immunoglobulin level ( J:113543 )

• levels of IgE produced in response to infection are equivalent to wild-type or, after 20 days, keep increasing at 40 days while wild-type levels decrease after 20 days

abnormal interleukin level ( J:113543 )

• IL-4 expression is 4-5 fold greater than wild-type at days 5, 10 and 20 after infection

• IL-10 expression is enhanced compared to wild-type

granulomatous inflammation ( J:113543 )

• primary granuloma formation and volumes in lungs after infection are reduced ~4-fold compared to wild-type

• formation of secondary granuloma formation is reduced compared to wild-type upon reinfection with Schistosoma eggs

abnormal susceptibility to infection ( J:113543 )

• expulsion of worms from intestines is delayed (50% by day 35) compared to wild-type (100% by 10 days)

increased susceptibility to parasitic infection ( J:113543 )

• after N. brasiliensis (nematode) infection, expulsion of worms occurs with similar kinetic to Il4/Il13 double mutants

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:113543 )

• increase in goblet cell number is delayed and occurs after 20 days compared to wild-type which show increased numbers at 10 days

hematopoietic system

increased eosinophil cell number ( J:113543 )

• eosinophilia is delayed compared to wild-type, but once induced, correlates with worm clearance

abnormal immunoglobulin level ( J:113543 )

• levels of IgE produced in response to infection are equivalent to wild-type or, after 20 days, keep increasing at 40 days while wild-type levels decrease after 20 days

homeostasis/metabolism

abnormal interleukin level ( J:113543 )

• IL-4 expression is 4-5 fold greater than wild-type at days 5, 10 and 20 after infection

• IL-10 expression is enhanced compared to wild-type

cellular

abnormal intestinal goblet cell morphology ( J:113543 )

• increase in goblet cell number is delayed and occurs after 20 days compared to wild-type which show increased numbers at 10 days