Phenotypes associated with this allele

• Allele Symbol: Del(2Hoxd1-Hoxd10)26Ddu
• Allele Name: deletion, Chr 2, Denis Duboule 26
• Allele ID: MGI:3689842
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(2Hoxd1-Hoxd10)26Ddu/Del(2Hoxd1-Hoxd10)26Ddu	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3689909
ht2	Del(2Hoxd1-Hoxd10)26Ddu/+	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5508537
ht3	Del(2Hoxd1-Hoxd10)26Ddu/+	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3690716

Genotype
MGI:3689909

hm1

• Allelic Composition: Del(2Hoxd1-Hoxd10)26Ddu/Del(2Hoxd1-Hoxd10)26Ddu
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:91567 )

limbs/digits/tail

abnormal autopod morphology ( J:91567 )

• loss of anterior posterior asymmetry and ectopic Hoxd13 and Hoxd11 expression

abnormal carpal bone morphology ( J:91567 )

• perfectly symetrical carpus

abnormal pollex morphology ( J:91567 )

• elongation of the thumb on the forelimbs

abnormal radius morphology ( J:91567 )

• the distal radius has the morphology of the distal ulna

abnormal limb development ( J:91567 )

• bilateral symmetry occurs in 8 of 8 right forelimbs but less frequently in left forelimbs

small limb buds ( J:91567 )

• reduced initial size

skeleton

abnormal carpal bone morphology ( J:91567 )

• perfectly symetrical carpus

abnormal radius morphology ( J:91567 )

• the distal radius has the morphology of the distal ulna

embryo

small limb buds ( J:91567 )

• reduced initial size

Genotype
MGI:5508537

ht2

• Allelic Composition: Del(2Hoxd1-Hoxd10)26Ddu/+
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

behavior/neurological

behavior/neurological phenotype ( J:199759 )

N • female mice exhibit normal courting behavior

Genotype
MGI:3690716

ht3

• Allelic Composition: Del(2Hoxd1-Hoxd10)26Ddu/+
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

limbs/digits/tail

polydactyly ( J:91567 )

• on forelimbs and hindlimbs