Phenotypes associated with this allele

• Allele Symbol: Six1^tm2Kwk
• Allele Name: targeted mutation 2, Kiyoshi Kawakami
• Allele ID: MGI:3689891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Six1^tm2Kwk/Six1^tm2Kwk	involves: 129P2/OlaHsd * C57BL/6	MGI:3690318

Genotype
MGI:3690318

hm1

• Allelic Composition: Six1^tm2Kwk/Six1^tm2Kwk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal trigeminal ganglion morphology ( J:114468 )

• at E13.5, numbers of neurons in the trigeminal ganglions is reduced compared to wild-type, Six1-deficient, Six4-deficient, and Six1,Six4 heterozygous mice (double mutants: ~15000 neurons/gangion vs controls: ~50000 neurons/ganglion)

abnormal nervous system physiology ( J:114468 )

• E10.5 mutant neurons can not survive in culture in presence of NT-3 or NGF whereas double heterozygous neuron survive for 30 hours in presence of NT-3

increased neuron apoptosis ( J:114468 )

• number of pyknotic cells in trigeminal ganglia at E10.5 is increased in double mutants vs controls

• at E12.5, there is a <7fold-increase in neuronal cells positive for cleaved caspase-3 in the trigeminal ganglia compared to control

cellular

increased neuron apoptosis ( J:114468 )

• number of pyknotic cells in trigeminal ganglia at E10.5 is increased in double mutants vs controls

• at E12.5, there is a <7fold-increase in neuronal cells positive for cleaved caspase-3 in the trigeminal ganglia compared to control