Phenotypes associated with this allele

• Allele Symbol: Abcc3^tm1Kruh
• Allele Name: targeted mutation 1, Gary D Kruh
• Allele ID: MGI:3689906
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc3^tm1Kruh/Abcc3^tm1Kruh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3690454
cx2	Abcc3^tm1Kruh/Abcc3^tm1Kruh Slc51a^tm1Pda/Slc51a^tm1Pda	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:3790667

Genotype
MGI:3690454

hm1

• Allelic Composition: Abcc3^tm1Kruh/Abcc3^tm1Kruh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:114229 )

N • in the absence of bile duct ligation, no significant differences in liver function are detected and serum and hematological properties are similar to wild-type

homeostasis/metabolism

increased circulating bilirubin level ( J:114229 )

• increase in serum levels of conjugated bilirubin after bile duct ligation is significantly depressed compared to wild-type mice

abnormal bile salt level ( J:114229 )

• 3 days after bile duct ligation liver bile acid levels are increased 1.5-fold

• however, in the absence of bile duct ligation, no significant differences in liver function or bile physiology are detected and serum and hematological properties are similar to wild-type

Genotype
MGI:3790667

cx2

• Allelic Composition: Abcc3^tm1Kruh/Abcc3^tm1Kruh; Slc51a^tm1Pda/Slc51a^tm1Pda
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal bile salt homeostasis ( J:132778 )

• in everted gut sac experiments, the transileal taurocholate (TC) transport is reduced more than in single Osta homozygotes, indicating further impairment in intestinal bile acid transport

• efflux of taurocholate from tissue to the serosal side (amount of TC in serosal fluid/TC associated with tissue) is decreased