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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4ratm2Fbb
targeted mutation 2, Frank Brombacher
MGI:3689995
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Il4ratm1Fbb/Il4ratm2Fbb
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * BALB/c MGI:3690928
cn2
 		Il4ratm2Fbb/Il4ratm2Fbb
Lyz2tm1(cre)Ifo/? 		involves: 129P2/OlaHsd * BALB/c MGI:5301111


Genotype
MGI:3690928
cn1
Allelic
Composition		 Il4ratm1Fbb/Il4ratm2Fbb
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Fbb mutation (0 available); any Il4ra mutation (46 available)
Il4ratm2Fbb mutation (0 available); any Il4ra mutation (46 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:114751 )
• mice succumb to Schistosoma infection in ~54 days

growth/size/body
weight loss ( J:114751 )
• progressive weight loss begins 6 weeks after S. mansoni infection; some animals lose 20% of original body weight

immune system
abnormal immune system physiology ( J:114751 )
• mice show a similar Th1 response to Il4ra-null mice and a Th2 response similar to wild-type in response to Schistosoma infection
abnormal macrophage physiology ( J:114751 )
• livers show impaired alternative macrophage activation compared to wild-type
granulomatous inflammation ( J:114751 )
• granulomas are similar to wild-type, but slightly larger and less compact: intestinal granulomas show massive inflammatory cell infiltration
liver inflammation ( J:114751 )
• granulomas form
decreased susceptibility to parasitic infection ( J:114751 )
• mice develop protective immunity against Nippostrongylus brasiliensis, accompanied by Th2 development
increased susceptibility to parasitic infection ( J:114751 )
• mice show 100% mortality during acute infection by Schistosoma mansoni; mean survival time is 54 days

liver/biliary system
liver inflammation ( J:114751 )
• granulomas form
liver fibrosis ( J:114751 )
• level of fibrosis is similar to wild-type

digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:114751 )
• during infection by N. brasiliensis, mice develop goblet cell hyperplasis

hematopoietic system
abnormal macrophage physiology ( J:114751 )
• livers show impaired alternative macrophage activation compared to wild-type

cellular
abnormal intestinal goblet cell morphology ( J:114751 )
• during infection by N. brasiliensis, mice develop goblet cell hyperplasis




Genotype
MGI:5301111
cn2
Allelic
Composition		 Il4ratm2Fbb/Il4ratm2Fbb
Lyz2tm1(cre)Ifo/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Fbb mutation (0 available); any Il4ra mutation (46 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased core body temperature ( J:178294 )
• susceptibility to cold induced hypothermia at both 22C and 4C
decreased fatty acids level ( J:178294 )
• reduced about 65% when exposed to 4C




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory