mortality/aging
• no homozygotes are found when E3.5 blastocyts are genotyped
|
reproductive system
• mutant allele is transmitted above Mendelian predicted level; heterozygous crosses (F1) transmit mutant allele more frequently than predicted (113 heterozygotes/139 total vs 26/139 wild-type offspring; <4:1 instead of 2:1)
• TRD is not apparent in backcrosses with F3 mice
|