Analysis Tools|
Allele Symbol Allele Name Allele ID |
Egln2tm1Fong targeted mutation 1, Guo-Hua Fong MGI:3690046 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no abnormalities in vessel number or size are detected unlike mice with conditional deletion of Egln1
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| N |
• unlike Egln2tm1Fong Egln3tm1Fongdouble homozygotes, single homozygotes do not display any hematological abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no cardiac or vascular developmental defects are detected
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| N |
• no placental defects are detected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2.4-fold increase in the number of hematopoietic stem cells in bone marrow derived cells
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• 4.3- and 3.6-fold increase in the number of erythroid progenitors in the spleen and liver, respectively, although no increase in hematopoietic activity is detected in a methylcellulose colony-forming activity
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• increase in red but not white cell counts in peripheral blood samples
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• in peripheral blood samples
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• in peripheral blood samples
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• increase in the number of erythroid progenitor cells
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• reddened snout especially in the area under the nostrils
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• reddened paws
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• increase in the number of erythroid progenitor cells
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• reddened paws and snout
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• reddened snout especially in the area under the nostrils
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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