Phenotypes associated with this allele

• Allele Symbol: Egln3^tm1Fong
• Allele Name: targeted mutation 1, Guo-Hua Fong
• Allele ID: MGI:3690047
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egln3^tm1Fong/Egln3^tm1Fong	involves: 129S6/SvEvTac * C57BL/6	MGI:3690227
hm2	Egln3^tm1Fong/Egln3^tm1Fong	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N	MGI:3783486
cx3	Egln2^tm1Fong/Egln2^tm1Fong Egln3^tm1Fong/Egln3^tm1Fong	involves: 129S6/SvEvTac * C57BL/6	MGI:3783538

Genotype
MGI:3690227

hm1

• Allelic Composition: Egln3^tm1Fong/Egln3^tm1Fong
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:132630 )

N • after 7 days ischemia induced by femoral artery ligation, mice display extensive muscle necrosis, similar in extent to wild-type animals

cardiovascular system

cardiovascular system phenotype ( J:133568 )

N • no abnormalities in vessel number or size are detected unlike mice with conditional deletion of Egln1

hematopoietic system

hematopoietic system phenotype ( J:132720 )

N • unlike Egln2^tm1Fong Egln3^tm1Fong double homozygotes, single homozygotes do not display any hematological abnormalities

Genotype
MGI:3783486

hm2

• Allelic Composition: Egln3^tm1Fong/Egln3^tm1Fong
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N

embryo

embryo phenotype ( J:114669 )

N • no placental defects are detected

cardiovascular system

cardiovascular system phenotype ( J:114669 )

N • no cardiac or vascular developmental defects are detected

Genotype
MGI:3783538

cx3

• Allelic Composition: Egln2^tm1Fong/Egln2^tm1Fong; Egln3^tm1Fong/Egln3^tm1Fong
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

hematopoietic system

enlarged spleen ( J:132720 )

abnormal definitive hematopoiesis ( J:132720 )

• 2.4-fold increase in the number of hematopoietic stem cells in bone marrow derived cells

extramedullary hematopoiesis ( J:132720 )

• 4.3- and 3.6-fold increase in the number of erythroid progenitors in the spleen and liver, respectively, although no increase in hematopoietic activity is detected in a methylcellulose colony-forming activity

polycythemia ( J:132720 )

• increase in red but not white cell counts in peripheral blood samples

increased hematocrit ( J:132720 )

• in peripheral blood samples

increased hemoglobin content ( J:132720 )

• in peripheral blood samples

abnormal splenic cell ratio ( J:132720 )

• increase in the number of erythroid progenitor cells

liver/biliary system

enlarged liver ( J:132720 )

craniofacial

abnormal snout morphology ( J:132720 )

• reddened snout especially in the area under the nostrils

limbs/digits/tail

abnormal autopod morphology ( J:132720 )

• reddened paws

reproductive system

decreased litter size ( J:132720 )

immune system

enlarged spleen ( J:132720 )

abnormal splenic cell ratio ( J:132720 )

• increase in the number of erythroid progenitor cells

integument

reddish skin ( J:132720 )

• reddened paws and snout

growth/size/body

abnormal snout morphology ( J:132720 )

• reddened snout especially in the area under the nostrils

enlarged liver ( J:132720 )

enlarged spleen ( J:132720 )