Phenotypes associated with this allele

• Allele Symbol: Pax3^tm5.1Buck
• Allele Name: targeted mutation 5.1, Margaret E Buckingham
• Allele ID: MGI:3690080
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax3^tm5.1Buck/Pax3^+	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:3690083

Genotype
MGI:3690083

cn1

• Allelic Composition: Pax3^tm5.1Buck/Pax3⁺
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:112275 )

• no live mice at birth, no specific time of death is given

muscle

abnormal myogenesis ( J:112275 )

• lack myogenic cells in the forelimb buds; however these cells are present in the hypoglossal cord and hindlimb buds

abnormal dermomyotome development ( J:112275 )

• foreshortening of the epaxial and hypaxial domains of the dermomyotome is reduced compared to homozygous Pax3^Sp mice at E10.5

nervous system

spina bifida ( J:112275 )

• reduced compared to homozygous Pax3^Sp mice and mice do no display exencephaly

embryo

spina bifida ( J:112275 )

• reduced compared to homozygous Pax3^Sp mice and mice do no display exencephaly