Phenotypes associated with this allele

• Allele Symbol: Bcl2^tm1Lbox
• Allele Name: targeted mutation 1, Linda M Boxer
• Allele ID: MGI:3690216
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2^tm1Lbox/Bcl2^tm1Lbox	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3692324

Genotype
MGI:3692324

hm1

• Allelic Composition: Bcl2^tm1Lbox/Bcl2^tm1Lbox
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:114637 )

• isolated B cells in culture show increased spontaneous apoptosis and increased sensitivity/apoptosis to chemotherapeutic agents

abnormal B cell differentiation ( J:114637 )

decreased immature B cell number ( J:114637 )

• numbers of immature B cells are decreased in the bone marrow

decreased B cell number ( J:114637 )

• numbers of B cells in the spleen and numbers of pre-B, immature B, and mature B cells in the bone marrow are decreased, with greater decreases as mice age, however no differences in the number of pro-B cells

decreased mature B cell number ( J:114637 )

decreased pre-B cell number ( J:114637 )

• numbers of pre-B cells are decreased in the bone marrow

abnormal B cell activation ( J:114637 )

• exhibit impaired activation of B cells to anti-IgM, LPS and anti-CD40

decreased B cell proliferation ( J:114637 )

• the proliferative response of B cells to anti-IgM, LPS and anti-CD40 is impaired due to increased apoptotic death

hematopoietic system

increased B cell apoptosis ( J:114637 )

• isolated B cells in culture show increased spontaneous apoptosis and increased sensitivity/apoptosis to chemotherapeutic agents

abnormal B cell differentiation ( J:114637 )

decreased immature B cell number ( J:114637 )

• numbers of immature B cells are decreased in the bone marrow

decreased B cell number ( J:114637 )

• numbers of B cells in the spleen and numbers of pre-B, immature B, and mature B cells in the bone marrow are decreased, with greater decreases as mice age, however no differences in the number of pro-B cells

decreased mature B cell number ( J:114637 )

decreased pre-B cell number ( J:114637 )

• numbers of pre-B cells are decreased in the bone marrow

abnormal B cell activation ( J:114637 )

• exhibit impaired activation of B cells to anti-IgM, LPS and anti-CD40

decreased B cell proliferation ( J:114637 )

• the proliferative response of B cells to anti-IgM, LPS and anti-CD40 is impaired due to increased apoptotic death

cellular

increased B cell apoptosis ( J:114637 )

• isolated B cells in culture show increased spontaneous apoptosis and increased sensitivity/apoptosis to chemotherapeutic agents

decreased B cell proliferation ( J:114637 )

• the proliferative response of B cells to anti-IgM, LPS and anti-CD40 is impaired due to increased apoptotic death