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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scarb1tm1Thh
targeted mutation 1, Thierry Huby
MGI:3690316
Summary 2 genotypes


Genotype
MGI:3697675
hm1
Allelic
Composition		 Scarb1tm1Thh/Scarb1tm1Thh
Genetic
Background		 B6.129X1-Scarb1tm1Thh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarb1tm1Thh mutation (0 available); any Scarb1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:114663 )
• 2-fold elevation in plasma total cholesterol levels that is associated with a corresponding 2-fold increase in free cholesterol
• on a high-fat, high-cholesterol, and cholic acid-containing atherogenic diet, plasma total cholesterol levels are elevated more than in controls
• hepatic content of free and esterified cholesterol is normal
increased circulating HDL cholesterol level ( J:114663 )
• marked elevation of HDL cholesterol

cardiovascular system
increased susceptibility to atherosclerosis ( J:114663 )
• atherosclerosis is enhanced 2.5-fold compared to controls, when fed an atherogenic (high-fat, high-cholesterol, and cholic acid-containing) diet




Genotype
MGI:3697677
cn2
Allelic
Composition		 Scarb1tm1Thh/Scarb1tm1Thh
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 B6.Cg-Scarb1tm1Thh Speer6-ps1Tg(Alb-cre)21Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarb1tm1Thh mutation (0 available); any Scarb1 mutation (53 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating cholesterol level ( J:114663 )
• elevation in plasma total cholesterol that is associated with more than 3-fold increase in free cholesterol
• high increase in plasma free cholesterol/plasma total cholesterol ratio
• develop severe hypercholesterolemia on an atherogenic diet due to an accumulation of free cholesterol-rich, VLDL-sized particles
• hepatic content of free and esterified cholesterol is normal
increased circulating HDL cholesterol level ( J:114663 )
• marked elevation of HDL cholesterol with abnormally large HDL particles
increased circulating interleukin-6 level ( J:114663 )
• on an atherogenic diet, IL-6 plasma levels are 6.6-fold greater than in wild-type

cardiovascular system
increased susceptibility to atherosclerosis ( J:114663 )
• atherosclerosis is enhanced 32-fold compared to controls, when fed an atherogenic (high-fat, high-cholesterol, and cholic acid-containing) diet

immune system
increased circulating interleukin-6 level ( J:114663 )
• on an atherogenic diet, IL-6 plasma levels are 6.6-fold greater than in wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory