About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scarb1tm1.1Thh
targeted mutation 1.1, Thierry Huby
MGI:3690317
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Scarb1tm1.1Thh/Scarb1tm1.1Thh B6.129X1-Scarb1tm1.1Thh MGI:3697678


Genotype
MGI:3697678
hm1
Allelic
Composition
Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic
Background
B6.129X1-Scarb1tm1.1Thh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarb1tm1.1Thh mutation (0 available); any Scarb1 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• elevation in plasma total cholesterol that is associated with more than 3-fold increase in free cholesterol
• high increase in plasma free cholesterol/plasma total cholesterol ratio
• develop severe hypercholesterolemia on an atherogenic diet due to an accumulation of free cholesterol-rich, VLDL-sized particles
• hepatic content of free and esterified cholesterol is normal
• marked elevation of HDL cholesterol with abnormally large HDL particles
• on an atherogenic diet, IL-6 plasma levels are 10.8-fold greater than in wild-type

cardiovascular system
• atherosclerosis is enhanced 48-fold compared to controls, when fed an atherogenic (high-fat, high-cholesterol, and cholic acid-containing) diet

reproductive system
• females are sterile when fed a normal chow diet, however fertility is restored when diet is supplemented with a lipid-lowering drug, probucol

immune system
• on an atherogenic diet, IL-6 plasma levels are 10.8-fold greater than in wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory