homeostasis/metabolism
• elevation in plasma total cholesterol that is associated with more than 3-fold increase in free cholesterol
• high increase in plasma free cholesterol/plasma total cholesterol ratio
• develop severe hypercholesterolemia on an atherogenic diet due to an accumulation of free cholesterol-rich, VLDL-sized particles
• hepatic content of free and esterified cholesterol is normal
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• marked elevation of HDL cholesterol with abnormally large HDL particles
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• on an atherogenic diet, IL-6 plasma levels are 10.8-fold greater than in wild-type
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cardiovascular system
• atherosclerosis is enhanced 48-fold compared to controls, when fed an atherogenic (high-fat, high-cholesterol, and cholic acid-containing) diet
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reproductive system
• females are sterile when fed a normal chow diet, however fertility is restored when diet is supplemented with a lipid-lowering drug, probucol
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immune system
• on an atherogenic diet, IL-6 plasma levels are 10.8-fold greater than in wild-type
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