All Phenotypes Hspa4l<tm1Imad> MGI Mouse

increased susceptibility to induced morbidity/mortality ( J:114659 )

• exhibit increased mortality after a 3% NaCl treatment, with all mutants dying on the third day of treatment while all wild-type survive

asthenozoospermia ( J:114659 )

• infertile males show a reduction in the proportions of motile and progressively motile sperm from the cauda epididymides

• fertile males show normal sperm concentrations but significantly reduced sperm motility

abnormal spermatogenesis ( J:114659 )

• although seminiferous tubules contain all stages of germ cells, the number of mature sperm in the epididymis is reduced due to increased apoptosis of developing germ cells

oligozoospermia ( J:114659 )

• infertile males show a significant reduction in the number of spermatozoa and increased apoptosis of germ cells

abnormal spermiation ( J:114659 )

• observe premature release of germ cells into the lumen

reduced male fertility ( J:114659 )

• 42% of males produce no offspring but generate vaginal plugs in females, indicating males are capable of mating

• the males that do produce offspring, produce small litters

abnormal kidney morphology ( J:114659 )

• 12% of 4 to 8 month old males exhibit massive unilateral or bilateral fluid-filled kidneys, however the ureters are not enlarged or dilated

abnormal kidney cortex morphology ( J:114659 )

• renal cortex is thinned in 12% of males

hydronephrosis ( J:114659 )

• Background Sensitivity: 12% of 4 to 8 month old males on the mixed 129 and C57BL/6J background exhibit moderate to severe dilation of the renal pelvis, indicating hydronephrosis, compared to none on a 129 background

• in most cases, hydronephrosis is seen in the right kidney of males

kidney atrophy ( J:114659 )

• hydronephrotic kidneys are accompanied by different degrees of atrophy of the renal parenchyma

abnormal kidney physiology ( J:114659 )

• kidneys exhibit increased susceptibility to osmotic stress, with mutants showing increased weight loss, mortality, and elevated plasma sodium, calcium, blood gases, and urea nitrogen after a 3% NaCl treatment

increased blood urea nitrogen level ( J:114659 )

• exhibit elevated blood urea nitrogen levels compared to wild-type after a 3% NaCl treatment

increased circulating calcium level ( J:114659 )

• exhibit elevated plasma calcium levels compared to wild-type after a 3% NaCl treatment

increased circulating sodium level ( J:114659 )

• exhibit elevated plasma sodium levels compared to wild-type after a 3% NaCl treatment

increased susceptibility to weight loss ( J:114659 )

• exhibit increased weight loss compared to wild-type after a 3% NaCl treatment

oligozoospermia ( J:114659 )

• infertile males show a significant reduction in the number of spermatozoa and increased apoptosis of germ cells

asthenozoospermia ( J:114659 )

• infertile males show a reduction in the proportions of motile and progressively motile sperm from the cauda epididymides

• fertile males show normal sperm concentrations but significantly reduced sperm motility

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24