mortality/aging
• normal numbers of homozygous embryos are found at E12.5 but number of viable embryos is severely reduced at E13.5
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nervous system
• there is a lack of Schwann cells and Schwann cell precursors in DRGs
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• there is a lack of Schwann cells and Schwann cell precursors in DRGs
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cardiovascular system
• mutants exhibit defects in the atrioventricular valves
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