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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il21tm1Llit
targeted mutation 1, L Li
MGI:3690462
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il21tm1Llit/Il21tm1Llit involves: 129 * C57BL/6J MGI:3696081


Genotype
MGI:3696081
hm1
Allelic
Composition		 Il21tm1Llit/Il21tm1Llit
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21tm1Llit mutation (0 available); any Il21 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:114783 )
• IgE isotype switch and IgE+ cell clonal expansion are dramatically enhanced in the spleen and IgE isotype switch is partially increased in the draining lymph nodes after OVA/alum immunization
increased IgE level ( J:114783 )
• IgE production of the pre-exisiting CD19-CD5+B220low IgE+ cells in the spleen is increased under physiological conditions

hematopoietic system
abnormal class switch recombination ( J:114783 )
• IgE isotype switch and IgE+ cell clonal expansion are dramatically enhanced in the spleen and IgE isotype switch is partially increased in the draining lymph nodes after OVA/alum immunization
increased IgE level ( J:114783 )
• IgE production of the pre-exisiting CD19-CD5+B220low IgE+ cells in the spleen is increased under physiological conditions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory