Phenotypes associated with this allele

• Allele Symbol: Tlr3^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:3690535
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr3^tm1Aki/Tlr3^tm1Aki	involves: 129P2/OlaHsd	MGI:3698173
cx2	Tlr3^tm1Aki/Tlr3^tm1Aki Tlr7^tm1Aki/Tlr7^tm1Aki	involves: 129P2/OlaHsd	MGI:6403489

Genotype
MGI:3698173

hm1

• Allelic Composition: Tlr3^tm1Aki/Tlr3^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal vascular smooth muscle physiology ( J:116310 )

• dsRNA fails to stimulate MCP-1 (monocyte chemoattractant protein-1) release from isolated mouse aorta smooth muscle cells (MAoSMC)

immune system

immune system phenotype ( J:144400 )

N • bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 produce normal levels of IFN-alpha

abnormal dendritic cell physiology ( J:114555 )

• poly(I:C)-induced expression of MHC II and costimulatory molecules is suppressed in mutant dendritic cells; maturation of dendritic cells is impaired

• dendritic cells show normal responses and maturation upon infection with NDV

cardiovascular system

abnormal vascular smooth muscle physiology ( J:116310 )

• dsRNA fails to stimulate MCP-1 (monocyte chemoattractant protein-1) release from isolated mouse aorta smooth muscle cells (MAoSMC)

Genotype
MGI:6403489

cx2

• Allelic Composition: Tlr3^tm1Aki/Tlr3^tm1Aki; Tlr7^tm1Aki/Tlr7^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

immune system

decreased interferon-alpha secretion ( J:144400 )

• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production