Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ss18tm1Adg targeted mutation 1, A Geurts van Kissel MGI:3690630 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: onset of embryonic lethality occurs earlier than in the mixed background as embryos show signs of resorption at E9.5, however stage when initiation of lethality occurs is not stated
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: lethality is initiated after E8.5 but before E9.5 and resorption is observed at E11.5 and E13.5, later than on a congenic C57BL/6 background
|
|
• about 50% exhibit a swollen heart
|
|
• 90% of E9.5 embryos exhibit growth retardation that varies from rudimentary embryos within the embryonic membranes to embryos lagging behind and estimated to be at E8.5
|
|
• exhibit little or no embryonic turning at E9.5
|
|
• developmental arrest occurs just after gastrulation as mutants show little or no embryonic turning
|
|
• 90% of E9.5 embryos exhibit growth retardation that varies from rudimentary embryos within the embryonic membranes to embryos lagging behind and estimated to be at E8.5
|
|
• neural tube is only partially closed at E9.5
|
|
• seen at E9.5
|
|
• exhibit impaired placental vascularization and vascular branching
• blood vessels are either located outside the placenta or exclusively near the base where the surrounding trophoblast tissue is very compact, and never in close proximity to the maternal sinuses
|
|
• the number of blood vessels in the prospective labyrinth is reduced
|
|
• chorionic plate of placentas is composed of densely packed trophoblasts and does not exhibit vascularization
|
|
• labyrinth development is disturbed
|
|
• impaired placental development, either through incomplete chorio-allantoic fusion or through a defect in the subsequent process of vascular branching morphogenesis
|
|
• observe the formation of an allantoic ball, indicating impaired chorioallantoic fusion
|
|
• about 50% exhibit dilated blood vessels in the head region
|
|
• exhibit impaired placental vascularization and vascular branching
• blood vessels are either located outside the placenta or exclusively near the base where the surrounding trophoblast tissue is very compact, and never in close proximity to the maternal sinuses
|
|
• the number of blood vessels in the prospective labyrinth is reduced
|
|
• about 50% exhibit a swollen heart
|
|
• about 50% are hemorrhagic
|
|
• neural tube is only partially closed at E9.5
|
|
• seen at E9.5
|
|
• exhibit oxygen shortage as indicated by hemorrhage, dilated blood vessels, and swollen heart
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• show an underrepresentation of heterozygotes at weaning, however stage of lethality is not specified
|
|
• 43% of E9.5 embryos exhibit growth retardation
|
|
• 43% of E9.5 embryos exhibit growth retardation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mutants are identified at E9.5 and E18.5 but not after birth, indicating perinatal lethality
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
