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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Marcotm1Ktry
targeted mutation 1, Karl Tryggvason
MGI:3690644
Summary 2 genotypes


Genotype
MGI:3696421
hm1
Allelic
Composition		 Marcotm1Ktry/Marcotm1Ktry
Genetic
Background		 B6.129S6-Marcotm1Ktry
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marcotm1Ktry mutation (5 available); any Marco mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:115081 )
• in a model of pneumococcal pneumonia, exhibit 100% lethality compared to 40% in wild-type

immune system
abnormal spleen marginal zone morphology ( J:122271 )
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus
abnormal macrophage physiology ( J:115081 )
• alveolar macrophages exhibit impaired in vitro binding of Streptococcus pneumoniae
impaired macrophage phagocytosis ( J:115081 )
• alveolar macrophages exhibit impaired in vivo uptake of unopsonized particles
increased inflammatory response ( J:115081 )
• homozygous mice treated with the inert environmental particle TiO2 show enhanced inflammation and chemokine expression compared to wild-type
increased susceptibility to bacterial infection ( J:115081 , J:122271 )
• in a model of pneumococcal pneumonia, homozygotes show an impaired ability to clear bacteria from the lungs, increased pulmonary inflammation and cytokine release, and diminished survival (J:115081)
• following immunization with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response (J:122271)

hematopoietic system
abnormal spleen marginal zone morphology ( J:122271 )
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus
abnormal macrophage physiology ( J:115081 )
• alveolar macrophages exhibit impaired in vitro binding of Streptococcus pneumoniae
impaired macrophage phagocytosis ( J:115081 )
• alveolar macrophages exhibit impaired in vivo uptake of unopsonized particles

cellular
impaired macrophage phagocytosis ( J:115081 )
• alveolar macrophages exhibit impaired in vivo uptake of unopsonized particles




Genotype
MGI:3714850
cx2
Allelic
Composition		 Marcotm1Ktry/Marcotm1Ktry
Msr1tm1Csk/Msr1tm1Csk
Genetic
Background		 B6.129-Marcotm1Ktry Msr1tm1Csk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marcotm1Ktry mutation (5 available); any Marco mutation (38 available)
Msr1tm1Csk mutation (5 available); any Msr1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen marginal zone morphology ( J:122271 )
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
increased IgM level ( J:122271 )
• anti-polysaccharide IgM levels are increased
abnormal macrophage physiology ( J:122271 )
• macrophage adhesion or spreading is absent
increased susceptibility to bacterial infection ( J:122271 )
• following immunization and infection with pneumoccocal bacterial serotype, mice have a decreased anti-polysaccharide IgM response
• following immunization and infection with pneumoccocal bacterial serotype, IgG3 response is virtually non-existent

hematopoietic system
abnormal spleen marginal zone morphology ( J:122271 )
• microarchitecture of the spleen marginal zone is altered
• marginal zones have fewer numbers of SIGNR1+ cells that do not tightly adhere to each other resulting in a gap between the marginal zone and the sinus that is more severe than in Marcotm1Ktry homozygotes
increased IgM level ( J:122271 )
• anti-polysaccharide IgM levels are increased
abnormal macrophage physiology ( J:122271 )
• macrophage adhesion or spreading is absent




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory